Vascular & Wound Care
Critical Limb Ischemia and chronic wounds:
Most common cause of non-healing wounds are peripheral arterial occlusive (PAD) and Diabetic Microangiopathy
Risk factors associated with the development of PAD include individuals aged 65 years and older, Nicotine use, Diabetes mellitus, hypertension, hypercholesterolemia, and family history of cardiovascular disease.
Open surgical techniques to remove the blockage (bypass) endovascular treatment (balloon angioplasty) is mainstay of revascularisation: While the mechanism of action has not been
Patients who have failed or who are no longer candidates for these therapies, 20% will die and 50–90% a leg amputation in 6 months.
Research focused on the use of autologous cell therapy has shown promise and has led to several clinical studies where concentrated autologous bone marrow cells have been used as an Angiogenic treatment in patients who are not candidates of open or endovascular procedure
How it is done
The mechanism of action is postulated is that the improvements shown in perfusion and concomitantly in quality of life and walking capacity result from the effect of bone marrow cells on the small collateral vessels. The expansion of these vessels is the most important physiological repair mechanism in peripheral artery disease
As a day care procedure 240 ml of Bone marrow OR 100 ml of fat is aspirated and processed for stem cells isolation. stem cells processed as per GMP are injected either into