Neurology

Neurology

Encouraging results have been observed in last few years in patients suffering from  various  NO OPTION neurodegenerative disorders ranging from:

  • Autism
  • Cerebral palsy
  • Spinal cord injury
  • Stroke
  • Parkinson’s
  • motor neuron disease
  • optic atrophy

How it works

1- HOMING

Because of Chemokines secreted by Damaged tissue

Neurotrophic Growth factors added along with stem cells

Blood-Brain Barrier:

  • Avoided using Intrathecal approach
  • Also made permeable by selective use of drugs

2-THERAPEUTIC ANGIOGENESIS

Because of presence of Endothelial Stem cell Population in Cocktail along with Platelets and Growth factors

Stem cell treatment induces angiogenesis, Predominantly responsible for tissue repair

Intravenous injection of MSCs after induced stroke resulted in augmented levels of endogenous VEGF as well as increased angiogenesis in transition zone

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3-REJUVENATION

Secrete growth factors which Modulate the Locoregional Milieu:

  • promote self-repair of residing tissue cells.
  • reactivate dormant neurons
  • Remyelination of Denuded Axons

Glial Cell-Line Derived Neurotrophic Factor (GDNF)
Brain-Derived Neurotrophic Factor (BDNF)
Nerve Growth Factor (NGF)
Vascular Endothelial Growth Factor (VEGF)
Hepatocyte Growth Factor (HGF)

4- REGENERATION 

Engraftment and Trans differentiation

After homing and subsequent survival of MSCs, their differentiation into neurons and astrocytes, leading to enhanced neural function (The concept of plasticity of stem cells or trans differentiation)

The Research behind the methodology

Intensive animal research and encouraging results from proof of concept studies support the concept;

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How it is done

Patients are evaluated clinically, radiologically by MRI, Pets cans, electrophysiological by EEG, evoked potentials 

As a day care procedure 240 ml of Bone marrow and 100 ml of fat is aspirated and processed for stem cells isolation. 5 ml of stem cells processed as per GMP is injected

INTRA-ARTERIAL (BBB)

INTRATHECAL (CSF BRAIN BARRIER)

DIRECT ONLY IN PATIENTS WITH SPINAL CORD INJURY

  • UNDER FLUOROSCOPIC GUIDANCE
  • OPEN-LIMITED LAMINECTOMY
  • OPEN SURGERY
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What to expect

AUTISM

  • 80% (8 of 10) experienced improvements.
  • Direct correlation between positive outcome and age, number of stem cells administered and frequency.
  • Results were significantly better in kids less than 8-year age.

CEREBRAL PALSY

  • Overall,60% improved
  • Cognitive improvements materialized after about 3 months and physical improvements started after 6 months.

SPINAL CORD INJURY

  • Nearly 65-70%% of the treated patients experienced improvements.
  • Up to 65% of patients recovered certain motor functions, increased muscle strength, better stamina during physical exercises, pelvic organs functions and improved bladder control as well as the sensitivity.

VOLUNTARY TRUNK MUSCLE CONTROL

  • Sitting without back support and able to stand with support is experienced by 85% of Patients with upper thoracic injury within 4 months.
  • Better coordination and walking ability with sensory improvement though motor scores did not improve much was observed in 90% of patients

USEFUL MOTOR AND SENSORY RECOVERY

  • Getting back sensation (feeling warm or cold sensations/ touch) was reported in 67% overall enhanced strength 65%
  • Improved muscle function and strength, including some ambulation seen in 60% Patients till about 2 years.

PARKINSONS

  • Total reversal of symptoms in the one patient.
  • 60 % of patients showed up to 50 %improvement in motor function

STROKE

  • Overall 75% patients experienced improvements.
  • MRI showed 25 % improvement in thickness of cortex in 60 % of patients

OPTIC ATROPHY

  • In sub-acute phase success rate exceeds up to 75 %.
  • improvement in the visual acuity in (58 %) of eyes.

Multiple sclerosis -

  • Treatment decreased tissue damage in the patients, and had the capacity to completely suppress further tissue damage
  • Upto 65 % of patients showed improved MS functional rating scale (EDSS) scale by at least 2 degree.
  • Total volume of lesions in the brain or spinal cord showed reduction up to 25 % in 40 % of patients (MRI)

Amyotrophic Lateral Sclerosis / Motor Neuron Disease

  • Patients showed improvement in 55 %, manual muscle testing of 34 muscle groups of the upper and lower limbs showed improvement by at least one grade in 60 % of patients
  • Electromyographic assessment of key muscle group of the upper and lower limb showed improvement in 50 % of patients
  • Somatosensory evoked potentials (SEPs) following tibial nerve stimulation showed improvement in 55 % of patients
  • MRIs – the spinal cord diameter at the level of engraftment showed increase in 80% of cases.
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The website contains no medical advice. All statements and opinions provided by the website are for educational and informational purposes. ||The treatment centres associated with Revita lifesciences provide surgical procedure only and are not involved in use or manufacture of any investigational drug ||Revita does not claim that any application or potential application, using autologous stem cells are approved by the FDA. We do not claim that these procedures work for any listed nor unlisted condition, intended or implied.||It’s important for potential patients to do their own research based on the options we present so that one can make an informed decision. Any decision to participate in experimental protocol is completely voluntary ||

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