Neurology
Neurology
Encouraging results have been observed in last few years in patients suffering from various NO OPTION neurodegenerative disorders ranging from:
- Autism
- Cerebral palsy
- Spinal cord injury
- Stroke
- Parkinson’s
- motor neuron disease
- optic atrophy



How it works
1- HOMING
Because of Chemokines secreted by Damaged tissue
Neurotrophic Growth factors added along with stem cells
Blood-Brain Barrier:
- Avoided using Intrathecal approach
- Also made permeable by selective use of drugs
2-THERAPEUTIC ANGIOGENESIS
Because of presence of Endothelial Stem cell Population in Cocktail along with Platelets and Growth factors
Stem cell treatment induces angiogenesis, Predominantly responsible for tissue repair
Intravenous injection of MSCs after induced stroke resulted in augmented levels of endogenous VEGF as well as increased angiogenesis in transition zone



3-REJUVENATION
Secrete growth factors which Modulate the Locoregional Milieu:
- promote self-repair of residing tissue cells.
- reactivate dormant neurons
- Remyelination of Denuded Axons
Glial Cell-Line Derived Neurotrophic Factor (GDNF)
Brain-Derived Neurotrophic Factor (BDNF)
Nerve Growth Factor (NGF)
Vascular Endothelial Growth Factor (VEGF)
Hepatocyte Growth Factor (HGF)
4- REGENERATION
Engraftment and Trans differentiation
After homing and subsequent survival of MSCs, their differentiation into neurons and astrocytes, leading to enhanced neural function (The concept of plasticity of stem cells or trans differentiation)
The Research behind the methodology
Intensive animal research and encouraging results from proof of concept studies support the concept;




How it is done
Patients are evaluated clinically, radiologically by MRI, Pets cans, electrophysiological by EEG, evoked potentials
As a day care procedure 240 ml of Bone marrow and 100 ml of fat is aspirated and processed for stem cells isolation. 5 ml of stem cells processed as per GMP is injected
INTRA-ARTERIAL (BBB)
INTRATHECAL (CSF BRAIN BARRIER)
DIRECT ONLY IN PATIENTS WITH SPINAL CORD INJURY
- UNDER FLUOROSCOPIC GUIDANCE
- OPEN-LIMITED LAMINECTOMY
- OPEN SURGERY






What to expect
AUTISM
- 80% (8 of 10) experienced improvements.
- Direct correlation between positive outcome and age, number of stem cells administered and frequency.
- Results were significantly better in kids less than 8-year age.
CEREBRAL PALSY
- Overall,60% improved
- Cognitive improvements materialized after about 3 months and physical improvements started after 6 months.
SPINAL CORD INJURY
- Nearly 65-70%% of the treated patients experienced improvements.
- Up to 65% of patients recovered certain motor functions, increased muscle strength, better stamina during physical exercises, pelvic organs functions and improved bladder control as well as the sensitivity.
VOLUNTARY TRUNK MUSCLE CONTROL
- Sitting without back support and able to stand with support is experienced by 85% of Patients with upper thoracic injury within 4 months.
- Better coordination and walking ability with sensory improvement though motor scores did not improve much was observed in 90% of patients
USEFUL MOTOR AND SENSORY RECOVERY
- Getting back sensation (feeling warm or cold sensations/ touch) was reported in 67% overall enhanced strength 65%
- Improved muscle function and strength, including some ambulation seen in 60% Patients till about 2 years.
PARKINSONS
- Total reversal of symptoms in the one patient.
- 60 % of patients showed up to 50 %improvement in motor function
STROKE
- Overall 75% patients experienced improvements.
- MRI showed 25 % improvement in thickness of cortex in 60 % of patients
OPTIC ATROPHY
- In sub-acute phase success rate exceeds up to 75 %.
- improvement in the visual acuity in (58 %) of eyes.
Multiple sclerosis -
- Treatment decreased tissue damage in the patients, and had the capacity to completely suppress further tissue damage
- Upto 65 % of patients showed improved MS functional rating scale (EDSS) scale by at least 2 degree.
- Total volume of lesions in the brain or spinal cord showed reduction up to 25 % in 40 % of patients (MRI)
Amyotrophic Lateral Sclerosis / Motor Neuron Disease
- Patients showed improvement in 55 %, manual muscle testing of 34 muscle groups of the upper and lower limbs showed improvement by at least one grade in 60 % of patients
- Electromyographic assessment of key muscle group of the upper and lower limb showed improvement in 50 % of patients
- Somatosensory evoked potentials (SEPs) following tibial nerve stimulation showed improvement in 55 % of patients
- MRIs – the spinal cord diameter at the level of engraftment showed increase in 80% of cases.



-
2 nd Floor Hb, Specialty Hospital & Research Institute, Near Bhoorarani Gate,
Kashipur Road, Rudrapur,
Udham Singh Nagar, Uttarakhand,
India 263153
- +915944240234, +919897080188
© 2023 Revita. All Rights Reserved. Made with ❤ by Puminati Digital