Current status & Rationale

Current status & Rationale

Current Status

stem-cell therapy could fundamentally change medicine, almost all treatments being developed are still in an experimental stage or under clinical trial, except for a few orthopaedic and cosmetic indications.

Autologous stem cells are most accepted as of now because of having advantages in terms of immune compatibility, lack of, and ethical issues.

Two major lines of investigation have emerged –one advocating stem cell enrichment only and the other doing expansion with or without differentiating these endogenous stem cells.

Enrichment has the advantage of fresh cells along with a cocktail of numerous different types of supportive cells and growth factors necessary for promoting cell growth.

The culture of stem cells increases the number but there are concerns about induction of mutations, changes in the behaviour of cells, etc.

Avoid the use of Cryo preserved cells as much as possible as on thawing viability is lost up to 25 %. Their death further increases during transportation. The biological behaviour also deteriorates. The ideal is fresh expanded /cultured cells directly from Lab.

Allogenic cells (not from the Patient’s own tissue) need more safety studies before clinical use

Rationale of use

Several published studies have documented the positive clinical effect of delivering autologous (patient’s own) bone marrow and adipose tissue-derived stromal cells. 

Our own results of pilot-human studies are very encouraging. 

Based on these available data, we are currently offering a safe and similar therapeutic approach to a small group of patients with various orthopaedic, cosmetic, neurodegenerative, Cardiac, Renal, hepatic, and metabolic (Diabetes) disorders.

Mechanism of Action

Stem cells help by secreting growth factors which help in new blood vessels formation (Neoangiogenesis) This leads to more blood supply hence better repair

Secrete lot of growth factors (of paracrine effect). It modulates the Locoregional Milieun hence Promoting self-repair of residing tissue cells. this also activates the dormant endogenous stem cells

 Few stem cells may also get Engrafted and Differentiate into component cell types and integrate with the target tissue


Clinical stem cell application should be done as a clinical trial in a few patients in those conditions where scientific evidence in literature is available. It should be followed by a placebo-controlled clinical trial on more Patients. ANY CENTRE CLAIMING OF DOING HUNDREDS OF CASES IN A PARTICULAR DISEASE IS NONSENSE.

Stem cell research and therapy should not be hyped but presented as a possible hope. The field needs time to grow and mature before stem cells can be turned into clinical and other applications. It will happen, but not right away.

Many hospitals and centres have overstated their stem-cell treatments with very bold claims.

Don’t be carried away with Testimonials as they can be generated Fake. Understand the Science and if willing kindly participate in it as an experiment.

The website contains no medical advice. All statements and opinions provided by the website are for educational and informational purposes. ||The treatment centres associated with Revita lifesciences provide surgical procedure only and are not involved in use or manufacture of any investigational drug ||Revita does not claim that any application or potential application, using autologous stem cells are approved by the FDA. We do not claim that these procedures work for any listed nor unlisted condition, intended or implied.||It’s important for potential patients to do their own research based on the options we present so that one can make an informed decision. Any decision to participate in experimental protocol is completely voluntary ||

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