Revita Life Sciences
Male Infertility
Male infertility/ Azospermia
About 15% of couples are infertile with 1 in 3 cases being due to male infertility. Testes produce androgens and sperms. Spermatogonial stem cells differentiate into mature spermatozoa in seminiferous tubules of the testes.
Bone marrow and adipose derived stem cells have the potential capabilities to replenish germ cells, supporting cells and testosterone producing cells hence when injected into seminiferous tubules or interstitial spaces are able to transdifferentiate into germ cells (spermatogonia and spermatocytes) and Sertoli and Leydig as well.
How It Is Done
Patients are evaluated for serum levels of gonadotrophins, testosterone and prolactin infectious genital disease, and anatomical abnormalities of the genital tract as these issues if present need to be corrected first.
Patients advised to strictly avoid smoking, drug or alcohol consumption.
As a day care procedure 120 ml of Bone marrow and 200 ml of fat is aspirated and processed in a closed system for stem cell isolation. 2 ml volume having at least 2 million stem cells per kg body weight is injected either into
*Intratesticular
*Into the feeding artery of testis
What To Expect
Appearance of normal healthy sperm cells at semen analysis is seen by 6 months in 60%.
- These sperms have Normal activity and possess the ability to fertilise ova (validated in lab).
- Fine needle aspiration (FNA) cytology reveals evidence of differentiation and Normal intra testicular spermatogenesis.
- 80% of Patients with oligospermia report significant increase (10 to 20 times) in sperm counts after 3 months of stem cell application.
